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Istradefylline forty mg/working day elevated peak ranges and AUC of CYP3A4 substrates in medical trials. This influence was not noticed with istradefylline 20 mg/day. Take into consideration dose reduction of delicate CYP3A4 substrates.ergotamine will increase the degree or effect of tazemetostat by impacting hepatic/intestinal enzyme CYP3A4 metabo